OPEN ACCESS

Articles online

Inflammatory Response and PM2.5 Exposure of Urban Traffic Conductors

Category: Air Pollution and Health Effects

Accepted Manuscripts
DOI: 10.4209/aaqr.2018.04.0132
PDF

Export Citation:  RIS | BibTeX

How-Ran Chao1,2, Jhih-Wei Hsu3,4, Hsiu-Ying Ku5, Shu-Li Wang3, Han-Bin Huang3,6, Saou-Hsing Liou3, Tsui-Chun Tsou 3

  • 1 Emerging Compounds Research Center, Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, Pingtung County 91201, Taiwan
  • 2 Institute of Food Safety Management, National Pingtung University of Science and Technology, Pingtung County 91201, Taiwan
  • 3 National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County 35053, Taiwan
  • 4 Department of Life Science, National Central University, Taoyuan City 32001, Taiwan
  • 5 National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan
  • 6 School of Public Health, National Defense Medical Center, Taipei City 11490, Taiwan

Highlights

Traffic-related PM2.5 and inflammation in traffic conductors were examined.
Blood proinflammatory activity was determined by NF-κB reporter assay.
Traffic conductors exhibit higher PM2.5 and proinflammation levels.
PM2.5 exposure is positively associated with proinflammatory activity.
Traffic-related PM2.5 potentially contributes to elevated inflammation.


Abstract

Human exposure to airborne PM2.5 has been linked to increased risk of respiratory and cardiovascular diseases, possibly via activation of systemic inflammation. However, associations between airborne PM2.5 and systemic inflammation in humans remained inconclusive. The traffic related air pollutants (TRAPs) are the major source of PM2.5 in urban areas; the adverse health effect of PM2.5 from TRAPs is currently a critical issue of public concern. The present cross-sectional study aimed to examine the relationship between PM2.5 exposure and systemic inflammation for considering health impacts of TRAP PM2.5 on urban traffic conductors. All study participants, i.e., office policemen (the reference) and traffic conductors (the exposure), were requested to carry a personal sampler to determine individual PM2.5 exposure. An adenovirus-based NF-κB luciferase reporter assay was used to determine proinflammatory activity in serum samples collected from the study participants. The blood proinflammatory activity was presented as tumor necrosis factor-α (TNFα) equivalence (TNFα-EQ), which was extrapolated from the sigmoidal semi-logarithmic dose-response curve of NF-κB reporter assay by TNFα. Levels of both personal PM2.5 exposure and blood proinflammatory activity (TNFα-EQ) in the exposure group (traffic conductors) were significantly higher than that in the reference group (office policemen) (p < 0.05). The present study revealed a positive and significant association between personal PM2.5 exposure levels and blood TNFα-EQ levels, in a linear regression model of y = 0.511x – 3.062 (y = log TNFα-EQ and x = log PM2.5) (R = 0.231 and p = 0.047); the result suggests that exposure to TRAP PM2.5 significantly contributes to the increased systemic inflammation in humans. The study provides clear evidence that long-term occupational exposure to TRAPs causes adverse health impacts, i.e., inflammation, on traffic conductors.

Keywords

Air pollution Health effects/risks Human exposure Personal exposure Toxicology


Related Article

Size Distribution of Ultrafine Particles Generated from Residential Fixed-bed Coal Combustion in a Typical Brazier

Daniel M. Masekameni , Derk Brouwer, Tafadzwa Makonese, Isaac T. Rampedi, Mary Gulumian
Accepted Manuscripts
DOI: 10.4209/aaqr.2018.03.0105
PDF

Effects of Hospital Ward Curtains on Ventilation in a Four-bed Hospital Ward

Jung-Hun Noh, Jungsuk Lee, Kwang-Chul Noh, Young-Won Kim, Se-Jin Yook
Accepted Manuscripts
DOI: 10.4209/aaqr.2017.11.0469
PDF
;