Opposing-pulse-jet technology has been proposed as a solution for regenerating filtration media by minimizing the incomplete cleaning of pleated filter cartridges. In this study, we investigated the effects of a pleated filter cartridge’s overall length and outer diameter (OD) on the performance of opposing-pulse-jet cleaning via numerical modeling. For each pleated filter cartridge, the delay time, Δt (defined as the delay in launching the secondary nozzle), was varied to analyze the intensity and the uniformity of the static pressure distribution in the core of the cartridge. It was found that two opposing jet flows collided much more intensely in the core when the length of the overall cartridge, L, was short, and the OD was small. For a given L, the pressure pulse’s performance was maximized by varying Δt. The pulse intensity and uniformity in the filter core can be represented as a bimodal (double-peaked) function of Δt. In general, the pulse intensity was greater when Δt > 0 s than when Δt < 0 s (when the secondary jet was launched before the primary jet).