Aerosol-cloud-precipitation interactions have attracted much more attention for decades, but there still remain many uncertainties in assessing global climate. Long-term ground-based measurements of aerosol, cloud and precipitation in Shanghai were used to examine their inter-annual variations and possible relationships. During 1990–2010, the yearly-averaged total cloud cover (TCC) and low cloud cover (LCC) decrease on average by 0.58% and 2.49% per year. LCC correlates to surface aerosols (e.g., PM10), with a correlation coefficient (R) of 0.67. Aerosol optical depth (AOD), as an indicator of columnar aerosol loading, shows a non-significant correlation with cloud cover. The yearly-aggregated heavy and extreme rain days and their rainfall amount increase gradually. The moderate rain day enhances but its annual rainfall amount declines year by year, while the light rain exhibits an opposite pattern to the moderate rain. These results imply that local aerosols maybe exert somewhat enforcing on low cloud and light rain through possible entrainment or updraft that can bring up surface particles into free troposphere, whereas its influence to total cloud and precipitation is negligible at a small scale. Future studies are needed to ensure whether local aerosols to directly affect low cloud, and to explore how surface aerosols to enter into higher atmospheric layers and impact cloud and precipitation at larger scales.