The aim of this study is to develop methodologies suitable for conducting multiple organic solvent exposure assessments for workers in plastic material printing industries. By reviewing the existing sampling and analytical methods for the seven organic solvents used in the industry (including isopropyl alcohol, 2-butanone, ethyl acetate, methyl isobutyl ketone, toluene, n-butyl acetate, and cyclohexanone), the coconut shell charcoal is suggested as the sorbent media for collecting samples and GC/FID is chosen as the instrument for chemical analyses. Both CS2 + 5% (v/v) 1-butanol and CS2 + 5% (v/v) isobutanol are proposed as candidate desorption reagents. Since the recovery rates obtained from the latter (83.47%–99.84%) were higher than those of the former (80.12%–98.00%), the latter was chosen in the present study. The linearity of all resultant calibration curves were found with r2 ≥ 0.995, recovery rates (R) ≥ 75%, and corresponding coefficient of variations (CV) ≤ 7% for all target organic solvents. Results also suggest that collected samples should be stored at the –10°C environment and be analyzed within 30 days. Finally, suggestions are made for amending the storage temperatures and storage days currently promulgated in related NIOSH methods based on data obtained from present study. The proposed methodology would be beneficial to the plastic material printing industry for simultaneously assessing workers’ exposures to multiple organic solvents.