The Guangdong and Hong Kong governments have collaboratively established the first Pearl River Delta regional air quality monitoring network (“PRD RAQMN”) since November 2005 which represented the first joint air quality monitoring of the regional air pollution and reporting efforts at a rapidly developed and heavy-polluted area in the southern China. The PRD RAQMN keeps track on the long-term evolution of air pollution status in the PRD region located in the south coast of China. It recorded the air quality trend during the 11th Five-Year Plan (FYP) implemented between 2006 and 2010, and the years of synchronous of leapfrogging economic development and stringent emission control on coal-fired power plants and vehicles for the 12th FYP to be implemented between 2011 and 2015. The PRD RAQMN showcases as a role model for the cooperation of local administrative authorities and also serves the surveillance system for joint prevention and management of air pollution. The PRD RAQMN catalyzed the cooperation among regions in the nation and public dissemination of air quality information which is otherwise under tight scrutiny in the past. The PRD RAQMN demonstrates that the regional collaboration and formation of consortium is critical in air quality management strategy to address and resolve the air pollution problems in China more effectively.